How to apply Radirex
Orally: adults and children over 12 years of age 2 tablets in a single dose, best before sleep. In case of necessity, it is possible to increase the dose to 3 tablets a day. Laxative effects occur after 6-8 hours.
The best individual dose is the smallest dose necessary to obtain soft stool.
In case of taking higher than recommended dose of Radirex
Overdose of the drug may cause serious diarrhea, leading to water-electrolyte balance disorders with typical consequences such as: cardiac rhythm disorders and muscular weakness. It is necessary to balance body fluids and electrolytes in case of overdose.
Before you apply Radirex
Contraindications for application of the drug include hypersensitivity to any of the preparation’s components, intestinal obstruction, intestinal atonia, acute and chronic inflammatory diseases of the intestines (ulcerative intestinal inflammation, Leśniowski-Crohn disease, among others), appendicitis, hemorrhoids, glomerulonephritis, oxolithiasis, diarrhea, dehydration and electrolyte disorders as well as stomach pains of unclear etiology.
Observe special care while applying Radirex, because
Similarly as in case of all other laxative agents, also Radirex should not be administered in case of any undiagnosed symptoms of acute or persistent belly ache.
If it is necessary to take laxatives every day, you should turn to a specialist for diagnosis of constipation causes. Avoid long term use of laxative agents.
In case of treatment with laxatives lasting over 2 weeks, physician’s supervision is necessary. Long term use may cause deposit of pigments in the intestinal mucosa (pseudomelanosis coli), however this is a harmless phenomenon which withdraws after discontinuation of the treatment.
Excessive use of Radirex® leading to fluid and electrolyte loss may cause dependence and necessity of taking larger doses of the drug in order to achieve laxative effect.
Excessive use may cause water-electrolyte balance disorders (mainly potassium level decrease), colon dysfunctions (loss of regular smooth muscle tonus).
Decrease of potassium level may also lead to cardiac disorders and neuro-muscular disorders, especially in case of simultaneous use of cardiac glycosides, diuretics or corticosteroids.
Long term use of laxative agents containing anthranoids may cause intensification of constipations.
Chronic use may lead to proteinuria and hematuria.
Application of laxative agents in case of chronic constipations cannot substitute necessity of diet change.
Avoid using during menstruation.
Application of Radirex in children
The drug should not be administered to children younger than 12 years of age.
Application of Radirex during pregnancy and breast feeding
Do not use the drug during pregnancy and breast feeding.
Driving of vehicles and operation of moving mechanisms
No negative influence of the drug on the ability to drive vehicles has been found.
Application of other drugs
Effects of cardiac glycosides may intensify in case of potassium level decrease caused by excessive use of rhubarb preparations. Potassium level decrease may also influence effects of the simultaneously applied anti-arrhythmic drugs and cardiac glycosides. Simultaneously used diuretic agents, adrenocortical steroids or licorice root may increase potassium loss.
Possible undesired effects
Usually no undesired effects are observed. Sporadically hypersensitivity reactions to the preparation components, such as diarrhea, potassium level decrease (hypokaliemia), stomach cramps and pains, especially in patients with irritable colon. Yellow or red-brown (depending on pH) urine color caused by the drug metabolites is clinically insignificant and disappears after its withdrawal.
Storage of Radirex
Store at the temperature not exceeding 25°C.
The drug should be stored out of reach and sight of children.
Do not use after expiry date stated on the package.
Rhei radix pulveratum, 513.5 mg, tablets
1 tablet contains:
Rhei radix pulveratum (pulverized rhubarb root) – 513.5 mg
1 tablet contains on the average 12.6 mg of anthranoid compounds converted into rheine
Packaging: 10 tablets.